Cell Applications Human Pulmonary Artery Smooth Muscle Cells: HPASMC

Cell Applications Human Pulmonary Artery Smooth Muscle Cells: HPASMC



Human Pulmonary Artery Smooth Muscle Cells (HPASMC) from Cell Applications, Inc. have been used to show that:

  • Antitumor drugs can selectively target remodeled pulmonary vessels, but not normal vessels
  • Serotonin induces their growth and activates the BMP receptor
  • IL-22 promotes the growth of pulmonary vascular SMCs via a signaling mechanism that involves NADPH oxidase-dependent oxidation
  • Inducers of pulmonary hypertension, characterized by thickened pulmonary arterial walls, can be suppressed by targeting gene transcription
  • Cell growth can be suppressed by trans-retinoic acid by inducing expression of a known cell growth suppressor,
  • Retinoic acid and its receptors may be involved in cell growth and pulmonary vascular remodeling
  • Iron chelation exerts effects on vascular remodeling and is implicated for development of pulmonary hypertension as a result of ROS activity


Normal human pulmonary artery.  Each lot is tested negative for HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi. 


Cryopreserved ampoule:

2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO.


Kit contains:

Ampoule of cryopreserved HPASMC (352-05a), 500 ml of Smooth Muscle Cell Media (311-500), and a Subculture Reagent Kit (090K).


Population doublings:

Can be cultured at least 16 doublings



Sahoo, S., D. Meijles, I. Ghouleh, M. Tandon, E. Cifuentes-Pagano, J. Sembrat, M. Rojas, E. Goncharova and P. Pagano. 2016. MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension. PLoS ONE, dx.doi.org/10.1371/journal.pone.0153780.
Ibrahim, Y.F., C.M. Wong, L. Pavlickova, L. Liu, L. Trasar, G. Bansal, and Y.J. Suzuki. 2014. Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug‐Induced Cell Killing. J. American Heart Association. 10.1161/jaha.1113.000520.


实验室玻璃器皿清洗消毒系统-G7883 CD蛋白浓缩器多孔细胞培养板标有刻度的量筒Macrosep Advance 离心浓缩管HyClone南美乌拉圭胎牛血清(FBS, South American Origin)easyall 去外泌体胎牛血清 Exosome-Depleted FBS
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